Should you take bupropion at night or in the morning?
Matthew Perez
Updated on June 05, 2026
Take bupropion in the morning to avoid trouble sleeping at night. If you're taking multiple doses throughout the day, separate the doses by at least 6-8 hours (depending on which form of bupropion you are taking) to lower the risk of seizures. If you miss a dose of bupropion, skip the dose.